Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes?

Ozkul, YUSUF; Erenmemisoglu, A; Ekecik, A; Saatci, ÇETİN; Özdamar, Saim; Demirtas, H

doi:10.1177/030006059602400110

Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes?

Ozkul Y., Erenmemisoglu A., Ekecik A., Saatci C., Özdamar S., Demirtas H.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.24, sa.1, ss.84-87, 1996 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 1
Basım Tarihi: 1996
Doi Numarası: 10.1177/030006059602400110
Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.84-87
Erciyes Üniversitesi Adresli: Hayır

Özet

The genetic toxicity of non-steroidal anti-inflammatory drugs was investigated using the sister chromatid exchange technique in cultured human lymphocytes. A total of 48 patients were treated with non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac or acetylsalicylic acid) for 2 weeks, The average numbers of sister chromatid exchanges in cultured lymphocytes from the patients, before and after treatment with these drugs, did not differ significantly (P > 0.05), These results indicate that treatment with non-steroidal anti-inflammatory drugs for 2 weeks does not induce sister chromatid exchanges in T lymphocytes.