Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes?


Ozkul Y. , Erenmemisoglu A., Ekecik A., Saatci C. , Özdamar S. , Demirtas H.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.24, no.1, pp.84-87, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 1996
  • Doi Number: 10.1177/030006059602400110
  • Title of Journal : JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Page Numbers: pp.84-87

Abstract

The genetic toxicity of non-steroidal anti-inflammatory drugs was investigated using the sister chromatid exchange technique in cultured human lymphocytes. A total of 48 patients were treated with non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac or acetylsalicylic acid) for 2 weeks, The average numbers of sister chromatid exchanges in cultured lymphocytes from the patients, before and after treatment with these drugs, did not differ significantly (P > 0.05), These results indicate that treatment with non-steroidal anti-inflammatory drugs for 2 weeks does not induce sister chromatid exchanges in T lymphocytes.