This study was aimed at determining the quality of sexual life and changes occurring in the sexual life of women with high-risk pregnancy. The study was carried out at the obstetric clinic of a hospital in a province located in the Central Anatolia region of Turkey. The population of this cross-sectional study comprised 112 women diagnosed with high-risk pregnancy. When the period during which the women had a diagnosis of high-risk pregnancy was compared to the period during which they did not have such a diagnosis, it was determined that more than half of the women experienced adverse changes in their sexual lives. Also high-risk pregnancies involved such complaints as sexual dissatisfaction, sexual self-dislike, and feelings of pain during sexual intercourse.