Akademik Veri Yönetim Sistemi
Frontiers in Psychiatry, cilt.16, 2025 (SCI-Expanded, SSCI, Scopus)
Introduction: Neuronal plasticity, or the ability to change and adapt in response to experiences, learning, or environment, is frequently disrupted in schizophrenia and contributes to disease-associated cognitive deficits and functional impairments. Methods: In this study, we investigated the neuroplasticity alterations of schizophrenia patients in the cortico-striato-cerebellar circuits associated with implicit learning using a reward-enhanced Serial Reaction Time Task (SRTT) by resting-state functional MRI (rs-fMRI). Forty-two schizophrenia patients and 25 healthy controls underwent pre- and post-task rs-fMRI to evaluate changes in functional connectivity. Results: Behavioral results indicated that all participants demonstrated shorter reaction times during sequential blocks, schizophrenia patients exhibited lower accuracy suggesting diminished implicit learning. Schizophrenia patients exhibited increased connectivity across cortico-striatocerebellar circuits, which became even more robust and widespread following task completion. Despite impaired performance, this post-task hyperconnectivity may reflect a compensatory mechanism attempting to recruit additional neural resources—albeit in a dysfunctional or inefficient manner. Data-driven analyses confirmed the post-task differences between groups, identifying task-induced connectivity changes in thalamo-cortico-cerebellar circuits as the strongest predictors of a group membership. Discussion: These findings underscore the role of neuroplasticity impairments in schizophrenia-related cognitive deficits, highlighting potential neural markers for clinical differentiation and paving the way for targeted interventions.