Akademik Veri Yönetim Sistemi
Materials Chemistry and Physics, cilt.317, 2024 (SCI-Expanded)
Green synthesis of nanoparticles, which is a safer and more environmentally friendly approach than traditional nanoparticle production methods, emerges as a promising field of the future. The green synthesis method, utilizing lichen extracts, offers a sustainable alternative to conventional nanoparticle production methods. Lichens have the ability to reduce and stabilize metallic salts, in addition to possessing medicinal effects from the secondary compounds they contain. In this context, the properties of lichens pave the way for a promising avenue in which nanotechnology can be harnessed within the field of cancer therapy. Building upon this back-ground, Diploschistes scruposus was employed in the production of nanoparticles through the green synthesis method. The study conducted the synthesis of lichen-derived silver-zinc oxide, silver-strontium oxide, and silver-nickel oxide nanoparticles, leveraging the characteristics of the Diploschistes scruposus species. It is specifically highlighted that toxicity studies concerning strontium oxide and nickel oxide nanoparticles are lacking. This aspect renders the study a valuable resource for addressing a significant knowledge gap in these fields and comprehending the potential biomedical applications of these nanoparticles. The properties of the resulting nanoparticles were determined through analysis of characteristic FE-SEM for morphological examination, and FT-IR was utilized to identify the presence of functional compo-nents. EDX methods were employed for elemental analysis, and XRD methods were used for crystal structure analysis. The hydrodynamic diameters of the nanoparticles were determined by DLS (Dynamic Light Scattering). In addition to characterization, the materials were tested for cytotoxi-city in breast cancer cells (MCF-7 and MDA-MB-231) using MTT test. According to the MTT assay, toxicity studies were dose-dependent and the lowest IC50 value was found in the MCF-7 cell line with Ag–ZnO at 4.25 ± 0.014 μg/mL.