Serum Vitamin D Levels Are Independently Associated With Severity of Coronary Artery Disease


Akin F., Ayca B., Kose N., Duran M., Sari M., Uysal O. K., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.60, no.6, pp.869-873, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.2310/jim.0b013e31825457cb
  • Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.869-873
  • Keywords: coronary artery disease, 25-hydroxyvitamin D, inflammatory markers, vitamin D, C-reactive protein, C-REACTIVE PROTEIN, 25-HYDROXYVITAMIN D LEVELS, BEAM COMPUTED-TOMOGRAPHY, TYPE-2 DIABETES-MELLITUS, SMOOTH-MUSCLE CELLS, 1,25-DIHYDROXYVITAMIN D-3, D DEFICIENCY, ENDOTHELIAL DYSFUNCTION, PARATHYROID-HORMONE, D SUPPLEMENTATION
  • Erciyes University Affiliated: Yes

Abstract

Background and Objectives: Low-serum vitamin D levels have been associated with increased cardiovascular risk in the general population. We hypothesized that serum vitamin D levels would be inversely associated with inflammation and with severity of coronary atherosclerosis. We therefore investigated the link between serum vitamin D levels and (1) the extent of coronary artery disease (CAD) assessed by the Gensini score and (2) inflammatory parameters, including C-reactive protein and fibrinogen.