A Comparison of the BEAM and MITO/MEL Conditioning Regimens for Autologous Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma: An Analysis of Efficiency and Treatment-Related Toxicity


Yeral M., Aytan P., Gungor B., Boga C., ÜNAL A. , Koc Y., ...More

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, vol.20, no.10, pp.652-660, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1016/j.clml.2020.05.009
  • Title of Journal : CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Page Numbers: pp.652-660
  • Keywords: Autologous transplantation, Conditioning, Lymphoma, Outcome, Stem cell, HIGH-DOSE CHEMOTHERAPY, BONE-MARROW-TRANSPLANTATION, SEQUENTIAL CHEMOTHERAPY, RESPONSE CRITERIA, MITOXANTRONE, BLOOD, THERAPY, CARMUSTINE, DISEASE

Abstract

In this multicenter retrospective study, we compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine, and melphalan) and MITO/MEL (mitoxantrone, melphalan) preparation regimens. The 3-year expected overall survival for the MIT/MEL and BEAM were 86.1% and 91.3%, respectively. The MITO/MEL seems to be as effective as the BEAM but has better tolerability in terms of pulmonary toxicity and may be used as an alternative option.