A Comparison of the BEAM and MITO/MEL Conditioning Regimens for Autologous Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma: An Analysis of Efficiency and Treatment-Related Toxicity

Yeral M., Aytan P., Gungor B., Boga C., ÜNAL A., Koc Y., ...Daha Fazla

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.20, sa.10, ss.652-660, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.clml.2020.05.009
  • Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.652-660
  • Anahtar Kelimeler: Autologous transplantation, Conditioning, Lymphoma, Outcome, Stem cell, HIGH-DOSE CHEMOTHERAPY, BONE-MARROW-TRANSPLANTATION, SEQUENTIAL CHEMOTHERAPY, RESPONSE CRITERIA, MITOXANTRONE, BLOOD, THERAPY, CARMUSTINE, DISEASE
  • Erciyes Üniversitesi Adresli: Evet

Özet

In this multicenter retrospective study, we compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine, and melphalan) and MITO/MEL (mitoxantrone, melphalan) preparation regimens. The 3-year expected overall survival for the MIT/MEL and BEAM were 86.1% and 91.3%, respectively. The MITO/MEL seems to be as effective as the BEAM but has better tolerability in terms of pulmonary toxicity and may be used as an alternative option.