Research on and clinical importance of duplications in various chromosomal regions in addition to Philadelphia chromosome in chronic myeloid leukemia


Sever T., Kilicarslan C., Pehlivan M., KAYNAR L. , Yilmaz M., ESER B. , ...More

JOURNAL OF BUON, vol.17, no.3, pp.490-496, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2012
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.490-496

Abstract

Purpose: To investigate the chromosomal aberrations in chronic myelogenous leukemia (CML), particularly in chromosomal regions which carried 67 genes pertaining to oncogenes, transcription factors, signal transduction, tumor suppressors, apoptosis etc, in addition to Philadelphia (Ph+) chromosome by multiplex ligation-dependent probe amplification (MLPA) method and to compare them with clinical parameters.