Research on and clinical importance of duplications in various chromosomal regions in addition to Philadelphia chromosome in chronic myeloid leukemia


Sever T., Kilicarslan C., Pehlivan M., KAYNAR L. , Yilmaz M., ESER B. , ...Daha Fazla

JOURNAL OF BUON, cilt.17, ss.490-496, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 3
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.490-496

Özet

Purpose: To investigate the chromosomal aberrations in chronic myelogenous leukemia (CML), particularly in chromosomal regions which carried 67 genes pertaining to oncogenes, transcription factors, signal transduction, tumor suppressors, apoptosis etc, in addition to Philadelphia (Ph+) chromosome by multiplex ligation-dependent probe amplification (MLPA) method and to compare them with clinical parameters.