Effect of cyclosporine A on total homocysteine level in a rabbit model

Sipahioglu M. H., Saglam E., Oymak O., Sav T., Tokgoz B., Karaca H., ...Daha Fazla

TRANSPLANTATION PROCEEDINGS, cilt.37, sa.5, ss.2371-2374, 2005 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.transproceed.2005.03.053
  • Dergi Adı: TRANSPLANTATION PROCEEDINGS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2371-2374
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background. Moderate hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Cyclosporine (CsA) has been suggested to interfere with folate-assisted remethylation of homocysteine, thus causing hyperhomocysteinemia. But, this issue is controversial. In this experimental study, we attempted to determine the association between CsA administration and total homocysteine levels. Working with rabbits that have normal creatinine levels, we obviated the misleading effects of renal functional variations, which are the most important confounding factors affecting total homocysteine level.