Formation of Colchicine-incorporated Hybrid Nanoflower With an Intrinsic Peroxidase-Mimic and Enhanced Antimicrobial Activities

Yılmaz E., Koca F. D., Satıcıoğlu İ. B., Özen B., Yilmaz D., Nisari M., ...Daha Fazla

CHEMISTRY & BIODIVERSITY, cilt.22, sa.10, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 10
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/cbdv.202500911
  • Dergi Adı: CHEMISTRY & BIODIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Anahtar Kelimeler: antimicrobial activity, colchicine, Cu-3(PO4)(2) crystal, Fenton reaction, nanoflower
  • Erciyes Üniversitesi Adresli: Evet

Özet

We report the formation of colchicine-Cu-3(PO4)(2) hybrid nanoflowers (Colc-NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H2O2). While the colchicine molecule, known as a secondary metabolite with anti-inflammatory properties, was used as an organic part of Colc-NFs, the Cu2+ ion acted as an inorganic part of Colc-NFs. The acetamide group in the colchicine structure may react with Cu2+ ions in phosphate-buffered saline to form Colc-NFs. The Colc-NFs exhibited both an intrinsic peroxidase-mimic activity against guaiacol and antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Candida albicans in the presence of H2O2. Both activities of the Colc-NFs rely on a Fenton-like reaction mechanism by producing reactive hydroxyl radicals. In addition to that high surface-to-volume ratio and porous structure of Colc-NFs may contribute to their peroxidase-mimic activities depending on the Fenton-like reaction.