DRUG AND CHEMICAL TOXICOLOGY, vol.38, no.1, pp.92-97, 2015 (SCI-Expanded)
In this study, the toxicokinetic of flumethrin after single oral and intravenous applications were studied. For this aim, 14 male New Zealand rabbits were used. The animals were divided into two groups of seven each. While 10 mg/kg.bw of flumethrin was intravenously injected into the first group, the same dose was administered orally with the second group. Serial blood samples were also collected at certain periods. Flumethrin concentrations were measured using a gas chromatography with a micro electron capture detector. The serum flumethrin concentration-time curve was determined to fit a two-compartment open model. Among the parameters calculated following intravenous application of flumethrin, the half-life at beta phase (t(1/2 beta)), mean residence time (MRT) and area under the concentration time curve in 0-infinity (AUC(0 ->infinity)) values were respectively found to be 34.0 +/- 4.2 h, 48.0 +/- 5.8 h and 36.1 +/- 5.3. On the other hand, the maximal concentration in serum (C-max), time needed to reach C-max (t(max)), t(1/2 beta), MRT and AUC(0 ->infinity) values of flumethrin after oral administration were determined to be 0.54 +/- 0.09 mu g/ml, 5.42 +/- 0.97 h, 43.3 +/- 8.6 h, 59.7 +/- 10.5 h and 22.0 +/- 2.0 mg.h/L, respectively. The bioavailability of flumethrin was found to be 60.9%. In conclusion, these results were considered to be important in terms of the toxication risk of flumethrin and its safe use.