Atıf İçin Kopyala
Kciuk M., Kołat D., Kałuzińska-Kołat Ż., Gawrysiak M., Drozda R., Çelik İ., ...Daha Fazla
CELLS, cilt.12, sa.4, ss.1-31, 2023 (SCI-Expanded)
-
Yayın Türü:
Makale / Tam Makale
-
Cilt numarası:
12
Sayı:
4
-
Basım Tarihi:
2023
-
Doi Numarası:
10.3390/cells12040530
-
Dergi Adı:
CELLS
-
Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
-
Sayfa Sayıları:
ss.1-31
-
Anahtar Kelimeler:
cytotoxic drugs, DNA damage response, immunotherapy, programmed death ligand-1 (PD-L1)
-
Erciyes Üniversitesi Adresli:
Evet
Özet
The application of immunotherapy for cancer treatment is rapidly becoming more widespread. Immunotherapeutic agents are frequently combined with various types of treatments to obtain a more durable antitumor clinical response in patients who have developed resistance to monotherapy. Chemotherapeutic drugs that induce DNA damage and trigger DNA damage response (DDR) frequently induce an increase in the expression of the programmed death ligand-1 (PD-L1) that can be employed by cancer cells to avoid immune surveillance. PD-L1 exposed on cancer cells can in turn be targeted to re-establish the immune-reactive tumor microenvironment, which ultimately increases the tumor’s susceptibility to combined therapies. Here we review the recent advances in how the DDR regulates PD-L1 expression and point out the effect of etoposide, irinotecan, and platinum compounds on the anti-tumor immune response.