Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris

Duran M., ELÇİK D., Inanc M. T., Yarlioglues M., Celik I. E., Oksuz F., ...More

BIOMARKERS IN MEDICINE, vol.14, no.6, pp.433-441, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.2217/bmm-2019-0319
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.433-441
  • Keywords: coronary artery disease, estimated glomerular filtration rate, mild renal dysfunction
  • Erciyes University Affiliated: Yes

Abstract

Aim: We investigated the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD) in people under 60 years of age. Materials & methods: A total of 634 (317 patients with vessel stenosis >= 50% and 317 with normal angiography) individuals diagnosed with stable angina pectoris and estimated glomerular filtration rate (eGFR) >= 60 ml/min/1.73m(2) were included in the present study. Results: The mean eGFR was lower (95.3 +/- 23.7 vs 109.7 +/- 22.3, respectively, p = 0.002) and the number of patients with MRD was higher in patients with CAD (137, 43.2%) than in the control group (52, 16.4%, p < 0.001). The multivariate analysis showed that lower eGFR is an independent risk factor for presence of CAD in people under 60 years of age with stable angina pectoris. Conclusion: According to our retrospective study, the risk of developing CAD appears to be slightly increased in individuals under 60 years of age with MRD.