Deneysel Olarak Oluşturulmuş Ekzojen Ateş, Hipertermi ve Buna Yönelik Kullanılan Bazı İlaçların Yavru Rat Beyni Üzerine Olan Etkilerinin Değerlendirilmesi


Aydın M., Ayar A., CANATAN H., Yılmaz B., Kabakuş N.

NOBEL MEDICUS, vol.8, no.3, pp.66-75, 2012 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 8 Issue: 3
  • Publication Date: 2012
  • Journal Name: NOBEL MEDICUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.66-75
  • Erciyes University Affiliated: Yes

Abstract

Objective: Hyperthermia may cause pathological changes in all systems and organs including the brain. Neuronal effects of exogenous fever (39°C) and hyperthermia (41°C), and efficacy of different medication modalities were studied in two-week-old infant female Wistar-Albino rats. Material and Method: Possible neuronal damage was evaluated by examining healthy, apoptotic and necrotic cells, and heat shock proteins (HSP, HSP 27 and HSP 70) in the cerebral cortex, cerebellum, and hypothalamus.Results: In both temperature groups, convulsion has been observed at different rates (25-37.5%). Three infant rats with convulsion in the group of 41 °C temperature were  died (n=3/9, 33.3%). At cellular level, when all neural 
tissues were taken into account; (i) considerable increase 
in number of necrotic neurons in both temperature groups 
(p=0.001, p=0.000), (ii) after 39°C fever, a decrease in 
number of healthy cells by diclofenac medication (p=0.02), 
an increase in number of necrotic cells by dexamethasone 
(p=0.02) and diclofenac (p=0.005) medications, (iii) after 
41°C hyperthermia, a decrease in number of necrotic 
cells by dexamethasone (p=0.000) and paracetamol 
medications (p=0.000) were observed. In the group of 
39°C fever, all medications were ineffective in terms of the 
number of apoptotic cells (p>0.05). 
Conclusion: In conclusion, results of the present study 
showed that neuronal tissue of various brain regions 
responded as different degree of damage or improvement 
to hyperthermic time course and applied medications. It 
was considered that these conflicting data might be due to 
the complexity of the brain. 
Key Words: Fever, hyperthermia, brain, neurons Nobel 
Med 2012; 8(3): 66-75