Copy For Citation
Aydın M., Ayar A., CANATAN H., Yılmaz B., Kabakuş N.
NOBEL MEDICUS, vol.8, no.3, pp.66-75, 2012 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
8
Issue:
3
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Publication Date:
2012
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Journal Name:
NOBEL MEDICUS
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.66-75
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Erciyes University Affiliated:
Yes
Abstract
Objective: Hyperthermia may cause pathological changes in all systems and organs including the brain. Neuronal effects of exogenous fever (39°C) and hyperthermia (41°C), and efficacy of different medication modalities were studied in two-week-old infant female Wistar-Albino rats. Material and Method: Possible neuronal damage was evaluated by examining healthy, apoptotic and necrotic cells, and heat shock proteins (HSP, HSP 27 and HSP 70) in the cerebral cortex, cerebellum, and hypothalamus.Results: In both temperature groups, convulsion has been observed at different rates (25-37.5%). Three infant rats with convulsion in the group of 41 °C temperature were died (n=3/9, 33.3%). At cellular level, when all neural
tissues were taken into account; (i) considerable increase
in number of necrotic neurons in both temperature groups
(p=0.001, p=0.000), (ii) after 39°C fever, a decrease in
number of healthy cells by diclofenac medication (p=0.02),
an increase in number of necrotic cells by dexamethasone
(p=0.02) and diclofenac (p=0.005) medications, (iii) after
41°C hyperthermia, a decrease in number of necrotic
cells by dexamethasone (p=0.000) and paracetamol
medications (p=0.000) were observed. In the group of
39°C fever, all medications were ineffective in terms of the
number of apoptotic cells (p>0.05).
Conclusion: In conclusion, results of the present study
showed that neuronal tissue of various brain regions
responded as different degree of damage or improvement
to hyperthermic time course and applied medications. It
was considered that these conflicting data might be due to
the complexity of the brain.
Key Words: Fever, hyperthermia, brain, neurons Nobel
Med 2012; 8(3): 66-75