Obesity is a major health problem threatening humanity in medical, social, and psychological dimensions. In this study, we aimed to determine the histological, immunohistochemical and biochemical effects of bee bread, added to diets of obese rats in different doses, on leptin and ghrelin expression. In the study, 40 female Sprague-Dawley (200-250 g) rats were randomly divided into 5 equal groups and then assigned to control and obesity groups. The obesity group consisted of four subgroups: high-fat diet group, 100 and 200mg/kg/bw groups, and mehformin group. Histopathological evaluation revealed structural deterioration and necrotic areas in the epithelium and glands of the obese rats' stomach tissue, while in their serum and gastric tissues, the MDA level was significantly higher than in the other groups. There was a negative correlation between leptin ghrelin levels. Apoptotic cells incresed with obesity, but the application of bee bread was similarly effective as a methformin administration in reducing this increase.