Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats


Creative Commons License

Doganyigit Z., YAKAN B. , Soylu M., Kaymak E., Okan A., SİLİCİ S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.121, ss.504-511, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 121 Konu: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4149/bll_2020_083
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Sayfa Sayıları: ss.504-511

Özet

Obesity is a major health problem threatening humanity in medical, social and psychological dimensions. In this study, we aimed to determine the histological, immunohistochemical and biochemical effects of bee bread, added to diets of obese rats in different doses, on leptin and ghrelin expression. In the study, 40 female Sprague-Dawley (200-250 g) rats were randomly divided into 5 equal groups and then assigned to control and obesity groups. The obesity group consisted of four subgroups: high-fat diet group, 100 and 200 mg/kg/bw groups, and metformin group. Histopathological evaluation revealed structural deterioration and necrotic areas in the epithelium and glands of the obese rats' stomach tissue, while in their serum and gastric tissues, the MDA level was significantly higher than in the other groups. There was a negative correlation between leptin and ghrelin levels. Apoptotic cells increased with obesity, but the application of beebread was similarly effective as metformin administration in reducing this increase (Tab. 5, Fig. 4, Ref. 51). Text in PDF www.elis.sk