Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3 beta and beta-catenin pathway in A549 cell line


Eren D. , Betul Y.

CHEMICO-BIOLOGICAL INTERACTIONS, cilt.258, ss.257-265, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 258
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cbi.2016.09.012
  • Dergi Adı: CHEMICO-BIOLOGICAL INTERACTIONS
  • Sayfa Sayıları: ss.257-265

Özet

Background and aim: In our study, anticancer effects of 6-gingerol, 6-shogaol from ginger and curcumin from turmeric were investigated and the results were compared with each other. We aimed to reveal their effects on microsomal prostaglandine E-2 synthase 1 (mPGES-1) which is related with cancer progression and inflammation as well as beta-catenin and glycogen synthase kinase 3 beta (GSK-3 beta) that are the main components of Wnt/GSK3 pathway. As it is known activation of GSK-3 beta and high levels of mPGES-1 pathway leads to cell proliferation and aggravates cancer progression. Therefore both of them are potential targets for cancer therapy. 6-shogaol and 6-gingerol' s effect on this pathway is not known very well up to now while curcumin that is known as an mPGES-1 inhibitor has anticancer properties via this pathway and many other pathways. Besides being in Zingiberaceae family, ginger's 6-gingerol and 6-shogaol have a molecular similarity with turmeric's curcumin. In our study we investigated their effects using a popular non small lung cancer cell line named A549 which expresses mPGES-1 and has active GSK3 beta pathway. IL-1 beta was used for inducing mPGES-1 and enabling the cancer characteristics such as cell proliferation. So compounds that inactivates or decreases the level of these components might be potential anticancer agents.