Evaluation of Paraoxonase1 Polymorphisms in Hypothyroid Patients and Their Relationship with Paraoxonase Activity and Serum Lipids

Caniklioglu, Aysen; BAŞKOL, GÜLDEN; BAYRAM, FAHRİ; ÖZKUL, YUSUF; Elmali, Ferhan; Cakir, Ilkay; Mert, Meral; Gunay, Nahide

doi:10.25179/tjem.2019-66617

Evaluation of Paraoxonase1 Polymorphisms in Hypothyroid Patients and Their Relationship with Paraoxonase Activity and Serum Lipids

Atıf İçin Kopyala

Caniklioglu A., BAŞKOL G., BAYRAM F., ÖZKUL Y., Elmali F., Cakir I., ...Daha Fazla

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.23, sa.4, ss.213-221, 2019 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 4
Basım Tarihi: 2019
Doi Numarası: 10.25179/tjem.2019-66617
Dergi Adı: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.213-221
Erciyes Üniversitesi Adresli: Evet

Özet

Objective: The risk for atherosclerosis increases in hypothyroidism, although its associated mode of pathogenesis has not been determined yet. Paraoxonase1 (PON1) is an enzyme that is antioxidative and antiatherogenic. This study was planned to determine distributions of PON1 192 and 55 gene polymorphisms in hypothyroid patients and healthy individuals and to investigate the effects of these polymorphisms on PON1 activity and serum lipids.