Evaluation of Paraoxonase1 Polymorphisms in Hypothyroid Patients and Their Relationship with Paraoxonase Activity and Serum Lipids
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.23, no.4, pp.213-221, 2019 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 23 Issue: 4
- Publication Date: 2019
- Doi Number: 10.25179/tjem.2019-66617
- Journal Name: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.213-221
- Open Archive Collection: AVESIS Open Access Collection
- Erciyes University Affiliated: Yes
Abstract
Objective: The risk for atherosclerosis increases in hypothyroidism, although its associated mode of pathogenesis has not been determined yet. Paraoxonase1 (PON1) is an enzyme that is antioxidative and antiatherogenic. This study was planned to determine distributions of PON1 192 and 55 gene polymorphisms in hypothyroid patients and healthy individuals and to investigate the effects of these polymorphisms on PON1 activity and serum lipids.