Evaluation of Paraoxonase1 Polymorphisms in Hypothyroid Patients and Their Relationship with Paraoxonase Activity and Serum Lipids

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Caniklioglu A., BAŞKOL G., BAYRAM F., ÖZKUL Y., Elmali F., Cakir I., ...More

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.23, no.4, pp.213-221, 2019 (ESCI) identifier identifier


Objective: The risk for atherosclerosis increases in hypothyroidism, although its associated mode of pathogenesis has not been determined yet. Paraoxonase1 (PON1) is an enzyme that is antioxidative and antiatherogenic. This study was planned to determine distributions of PON1 192 and 55 gene polymorphisms in hypothyroid patients and healthy individuals and to investigate the effects of these polymorphisms on PON1 activity and serum lipids.