Contribution of KIR (killer immunoglobulin-like receptor) genes, HLA class I ligands, and KIR/HLA class I ligand combinations on the genetic predisposition to celiac disease and coexisting celiac disease and type 1 diabetes mellitus


Akar H. H. , PATIROĞLU T. , Sevinc E. , Aslan D. , Okdemir D. , Kurtoglu S.

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, cilt.107, ss.547-553, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 107 Konu: 9
  • Basım Tarihi: 2015
  • Dergi Adı: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
  • Sayfa Sayısı: ss.547-553

Özet

Backgound and aim: There are some common genetic features between celiac disease (CD) and diabetes mellitus type 1 (DM). However, the genetic risk factors have not been fully clarified for CD and the co-occurrence of CD and DM. KIR (killer immunoglobulin-like receptor) genes regulate the cytolitic activity of NK-cells and T lymphocytes. The aim of this study is to evaluate the contribution of KIR genes, KIR ligands, and combinations of KIR/KIR ligands on the genetic predisposition to CD and co-occurrence of CD and DM.