Contribution of KIR (killer immunoglobulin-like receptor) genes, HLA class I ligands, and KIR/HLA class I ligand combinations on the genetic predisposition to celiac disease and coexisting celiac disease and type 1 diabetes mellitus

Akar H. H., PATIROĞLU T., Sevinc E., Aslan D., Okdemir D., Kurtoglu S.

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, vol.107, no.9, pp.547-553, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 9
  • Publication Date: 2015
  • Journal Name: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.547-553
  • Erciyes University Affiliated: Yes

Abstract

Backgound and aim: There are some common genetic features between celiac disease (CD) and diabetes mellitus type 1 (DM). However, the genetic risk factors have not been fully clarified for CD and the co-occurrence of CD and DM. KIR (killer immunoglobulin-like receptor) genes regulate the cytolitic activity of NK-cells and T lymphocytes. The aim of this study is to evaluate the contribution of KIR genes, KIR ligands, and combinations of KIR/KIR ligands on the genetic predisposition to CD and co-occurrence of CD and DM.