In vitro and clinical studies on the efficacy of alpha-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection

Paolacci, S.; Ergoren, M.; De Forni, D.; Manara, E.; Poddesu, B.; Cugia, G.; Dhuli, K.; Camilleri, G.; Tuncel, G.; Suer, H.; Sultanoglu, N.; Sayan, M.; DÜNDAR, MUNİS; Beccari, T.; Ceccarini, M.; Gunsel, I.; Dautaj, A.; Sanlidag, T.; Connelly, S.; Tartaglia, G.; Bertelli, M.

doi:10.26355/eurrev_202112_27337

In vitro and clinical studies on the efficacy of alpha-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection

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Paolacci S., Ergoren M. C., De Forni D., Manara E., Poddesu B., Cugia G., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.25, pp.81-89, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 25
Publication Date: 2021
Doi Number: 10.26355/eurrev_202112_27337
Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Page Numbers: pp.81-89
Keywords: SARS-CoV-2, ACE2, Hydroxytyrosol, alpha-cyclodextrin
Erciyes University Affiliated: Yes

Abstract

OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus responsible for the current pandemic of coronavirus disease 2019 (COVID-19). This virus attacks cells of the airway epithelium by binding transmembrane angiotensin-converting enzyme 2 (ACE2). Hydroxytyrosol has anti-viral properties. Alpha-cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. The aim of the present experimental study was to evaluate the efficacy of alpha-cyclodextrin and hydroxytyrosol in improving defenses against SARS-CoV-2 infection in in vitro cell models and humans.