The present study examined the correlation between anxiety scores and skin conductance level in 29 male Swiss Albino mice. Skin conductance (SC) was recorded with the SC unit and IBM-AT computer. Anxiety scores of mice were obtained from the elevated plus-maze test. The main result of the present study indicates that SC levels (SCLs) are negatively correlated with plus-maze behavior scores (both entries and time spent on the open arms). Our results are consistent with the findings which suggests that the higher the anxiety level the higher the SCL. This study further demonstrates the utility of SCL as a measurement for identifying anxiety in mouse. The interrelation between SCLs and plus-maze scores and possible explanations of the results are discussed. (C) 1998 Elsevier Science Inc.