Comparison of natural NQO2 inhibitors as a new target for cancer treatment in different cell lines


Yerer M. B. , DEMİRPOLAT E. , CUMAOĞLU A. , Torcuk C. , Imamoglu N. N. , Kosar M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.40, ss.224-233, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/tjb-2015-0006
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.224-233

Özet

Objective: Quinones are highly reactive compounds undergoing either one-or two-electron reductions. Enzymatic one-electron reduction generates unstable semiquinone radicals which readily undergo redox cycling over NQO1 and NQO2 enzymes, in the presence of molecular oxygen, leading to the production of highly reactive oxygen species (ROS). NQO1 is responsible form detoxification where NQO2 inhibitors are found to show potent anticancerogenic effects. The aim of this study is to investigate some natural inhibitors of the NQO2 enzyme and to identify their action mechanisms over this enzyme on different cancer cell lines.