Serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3) and leptin levels are related to abdominal aortic intima-media thickness in macrosomic newborns


Koklu E. , Kurtoglu S. , Akçakuş M. , Yıkılmaz A. , Güneş T.

GROWTH HORMONE & IGF RESEARCH, cilt.17, ss.26-32, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 17 Konu: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.ghir.2006.10.002
  • Dergi Adı: GROWTH HORMONE & IGF RESEARCH
  • Sayfa Sayısı: ss.26-32

Özet

Objective: Exposure to diabetes in utero has been established as a significant risk factor for some of the components of metabolic syndrome, and was associated with increased levels of maternal, placental, and fetal insulin-like growth factors and leptin. The atherogenic effects of leptin and insulin-like growth factor-I (IGF-I) have been extensively described. The present study was therefore designed to investigate relationships between abdominal aortic intima-media thickness (aIMT), serum IGF-I, IGF binding protein-3 (IGFBP-3) and leptin levels in macrosomic newborns.