Outcomes of transcorneal electrical stimulation therapy in the early stages of retinitis pigmentosa

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Demir M. N., Acar U., Sobaci G., GÖKSÜLÜK D.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.52, sa.3, ss.741-746, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0144.5368
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.741-746
  • Anahtar Kelimeler: Multifocal electroretinography, retinitis pigmentosa, tes therapy, transcorneal electrical stimulation, visual field, RETINAL GANGLION-CELLS, OPTIC NEUROPATHY, VISUAL-ACUITY, SURVIVAL, PHOTORECEPTORS, PROMOTES, TRIAL
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background/aim: To investigate the effect of transcorneal electrical stimulation (TES) therapy in patients with retinitis pigmentosa (RP). Materials and methods: We performed TES therapy in 21 patients with RP in 12 sessions with 1-week intervals. The following parameters obtained before and after the TES therapy were compared statistically; the best corrected visual acuity (BCVA, logMAR), Ishihara color vision level, multifocal electroretinography (mf-ERG) response, automated visual field (VF) outcome, and the 25-item low vision quality-of-life (LVQOL) questionnaire points. Results: The mean age of patients (6 females; 15 males) was 31.67 ?? 9.80 years (20???50 years). While increases in BCVA level, color vision level, mf-ERG response in p1 amplitude of ring 1, and LVQOL questionnaire points were statistically significant, changes in VF test and other mf-ERG responses were not. Twenty of the patients (95.24%) stated that they were satisfied with the TES therapy. No considerable side effect was observed in any patient due to the therapy. Conclusion: The TES therapy may be an effective and safe treatment modality in slowing the RP progression, especially in the early stages of the disease. Longer-term follow-ups in larger patient populations are warranted.