Synthesis and antimicrobial evaluation of novel 5-substituted-2-(p-tert-butylphenyl)benzoxazoles

Tasci M., Temiz-Arpaci O., Kaynak-Onurdag F., ÖKTEN S.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, cilt.57, sa.3, ss.385-389, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 3
  • Basım Tarihi: 2018
  • Dergi Adı: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.385-389
  • Anahtar Kelimeler: Benzoxazole, synthesis, antimicrobial activity, BENZOXAZOLES, INHIBITORS, ANALOGS, LYASE
  • Erciyes Üniversitesi Adresli: Evet

Özet

In the present study, a series of nine novel 5-substituted-2-(p-tert-butylphenyl)benzoxazole derivatives have been synthesized and their structures confirmed by spectral techniques and also tested for their antimicrobial activities. The minimum inhibitory concentrations (MIC) of the new benzoxazoles have been determined against standard bacterial and fungal strains and drug-resistant isolates and compared to those of several reference drugs. The new benzoxazole derivatives are found to possess a broad spectrum of antibacterial activity with MIC values of 8-256 mu g/mL. Especially, compound 9 is more active than standard drugs ciprofloxacin and cefotaxime against E. coli isolate with a MIC value of 8 mu g/mL. Also new compounds are less active than fluconazole with a MIC value of 256 mu g/mL against C. albicans and its isolate except for compound 9 that shows better activity other compounds with a MIC value of >4 mu g/mL for their antifungal activity.