Effects of vitamin A and C and melatonin on 3-nitrotyrosine formation in guinea pig heart under lipopolysaccharide-induced stress


Yaman H., Cayci T., Seyrek M., Akgul E. O. , Kurt Y. G. , Aydin I., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.40, ss.715-721, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3906/sag-0906-71
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.715-721

Özet

Aim: Bacterial lipopolysaccharide (LPS) triggers synthesis of nitric oxide (NO) and superoxide (O(2)(-)).O(2)(-) can react with NO to produce the powerful oxidant peroxynitrite (ONOO(-)). The presence of 3-nitrotyrosine (3-NT) in tissues is often used as a marker of ONOO(-) production. Vitamin A, vitamin C, and melatonin are potent antioxidant molecules. We sought to clarify this issue by examining the effects of vitamin A (15,000 IU/kg/day), vitamin C (600 mg/kg/day), and melatonin (25 mg/kg) on 3-NT formation in heart tissue in a guinea pig model of LPS-induced endotoxemia.