Effect of granulocyte colony-stimulating factor in experimental methicillin resistant Staphylococcus aureus sepsis

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ALP E., GOZUKUCUK S., CANOZ O., KIRMACI B., Doganay M.

BMC INFECTIOUS DISEASES, vol.4, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4
  • Publication Date: 2004
  • Doi Number: 10.1186/1471-2334-4-43
  • Journal Name: BMC INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Erciyes University Affiliated: Yes

Abstract

Background: Methicillin resistant Staphylococcus aureus (MRSA) is the leading pathogenic cause of nosocomial infections, especially in bacteraemia and sepsis. The essential therapy for MRSA infection is glycopeptides. Therapeutic failure can be seen with this therapy and the mortality is still high. The aim of this study was to evaluate the additional effect of G-CSF on the traditional antibiotic treatment in an experimental MRSA sepsis.