High Levels of Serum Uric Acid Predict Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Duran M., KALAY N., Akpek M., Orscelik O., ELÇİK D., Ocak A., ...Daha Fazla

ANGIOLOGY, cilt.63, sa.6, ss.448-452, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/0003319711426868
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.448-452
  • Anahtar Kelimeler: serum uric acid, Gensini score, acute coronary syndrome, HEART-DISEASE, ENDOTHELIAL DYSFUNCTION, CARDIOVASCULAR-DISEASE, INDEPENDENT PREDICTOR, RENAL-FUNCTION, ALL-CAUSE, RISK, HYPERURICEMIA, ASSOCIATION, MORTALITY
  • Erciyes Üniversitesi Adresli: Evet

Özet

We aimed to elucidate the relation between serum uric acid (SUA) level and severity of coronary artery disease (CAD) in nondiabetic, nonhypertensive patients (n = 246) with acute coronary syndrome (ACS). Severity of CAD was assessed by the Gensini score. One, 2, and 3 or more diseased vessels were identified in 87 (35.4%), 55 (22.4%), and 104 (42.2%) patients, respectively. Patients with hyperuricemia had higher Gensini score, high number of diseased vessels, critical lesions, and total occlusion. Serum uric acid level was significantly associated with number of diseased vessels. Serum uric acid was an independent risk factor for multivessel disease by univariate analysis. High levels of SUA associated with the severity of CAD in nondiabetic, nonhypertensive patients with ACS.