Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1H-Pyrimidin-2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues

Aydın H., Korkusuz E., Yıldırım İ.

Letters In Organic Chemistry, sa.18, ss.1-6, 2021 (SCI Expanded İndekslerine Giren Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1570178617999201014165048
  • Dergi Adı: Letters In Organic Chemistry
  • Sayfa Sayıları: ss.1-6


A one-pot three component synthesis of a series of new gramine derivatives was designed

and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl

amines at 80-110 oC for 10-24 hours in an oven under solvent- and catalyst-free conditions

providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and

N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were

conveniently synthesized and characterized by elemental analyses, FT IR, 1H and 13C NMR spectroscopic