Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1H-Pyrimidin-2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues

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Aydın H., Korkusuz E., Yıldırım İ.

Letters In Organic Chemistry, vol.18, no.9, pp.703-709, 2021 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 18 Issue: 9
• Publication Date: 2021
• Doi Number: 10.2174/1570178617999201014165048
• Journal Name: Letters In Organic Chemistry
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
• Page Numbers: pp.703-709
• Open Archive Collection: AVESIS Open Access Collection
• Erciyes University Affiliated: Yes

Abstract

A one-pot three component synthesis of a series of new gramine derivatives was designed

and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl

amines at 80-110 oC for 10-24 hours in an oven under solvent- and catalyst-free conditions

providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and

N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were

conveniently synthesized and characterized by elemental analyses, FT IR, 1H and 13C NMR spectroscopic

measurements.