Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis


Kose K. , Utaş S. , Yazici C. , Akdas A. , Kelestimur F.

BRITISH JOURNAL OF DERMATOLOGY, vol.144, no.6, pp.1121-1126, 2001 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 144 Issue: 6
  • Publication Date: 2001
  • Doi Number: 10.1046/j.1365-2133.2001.04221.x
  • Title of Journal : BRITISH JOURNAL OF DERMATOLOGY
  • Page Numbers: pp.1121-1126

Abstract

Background T-cell activation has been implicated in the pathogenesis of psoriasis; adenosine deaminase (ADA) activity has been considered as a marker of T-cell activation. The antithyroid drug propylthiouracil (PTU) has recently been shown to have beneficial effects on psoriatic lesions, probably by acting on the immune system.