Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2

Yetişkin H., Kaplan B., Pavel S. T. I., Özdarendeli A.

FRONTIERS IN IMMUNOLOGY, vol.13, pp.824378, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2022
  • Doi Number: 10.3389/fimmu.2022.824378
  • Journal Name: FRONTIERS IN IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.824378
  • Keywords: exosome, extracellular vehicles (EVs), COVID-19, SARS-CoV-2, convalescence plasma, viral treatment, ACUTE RESPIRATORY SYNDROME, COVID-19, VENTILATION, RESPONSES, VESICLES
  • Erciyes University Affiliated: Yes

Abstract

The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models.