Comparison of the effect of the different consantrations of bupivacaine on stress response and postoperative analgesia in caudal analgesia Kaudal analjezi̇de i̇ki̇ farkli konsantrasyonda bupi̇vakai̇n'i̇n stres yanit ve postoperati̇f analjezi̇ üzeri̇ne etki̇leri̇ni̇n karşilaştirilmasi

Öksüz H., Şenoǧlu N., ÖZKAN K. U.

Anestezi Dergisi, vol.17, no.2, pp.86-90, 2009 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2009
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.86-90
  • Erciyes University Affiliated: No


Introduction: Caudal epidural anaesthesia is used worldwide and is an attractive method to provide effective and satisfactory analgesia for perioperative pain in control children. The procedure was administered for caudal block in children scheduled for inguinal hernia operation and designed to compare two different dose regimens of bupivacaine on hormonal reaction according to stress and to asses its effect on post-operative analgesia. Method: 80 ASA I-II, aged betwen 4-10 years old patients were randomly divided into two different groups after the approvel of the ethic committee and parents' informed consent. Anesthesia induction was achieved by sevofluorane and cisatracurium, after intubation, cases were set to lateral decubitus position. Caudal block achieved 0.125 % bupivacaine in the first group (Group A) and 0.25 % in the second group (Group B) at 1 mL kg-1 dosage. Cases were treated with sevufluorane 1-2 % minimum alveolar concentration (MAC) and 50 % O2-N2O without any opioid agents for the anesthesia continuation. Cases were examined for blood glocose, cortisole levels before caudal block and at 30 minutes after the discontinuation of the surgery. Cases were evaluated by objective pain scala (OPS) in the first 24 hours after the surgery and with scores greater than 5 were treated with intrarectal paracetamol (30 mg kg-1) Results: There were no statistically significant differences among the demographic data and surgery time of the cases (p>0.05). Stress hormones levels and pain scores and also avarage supplemental analgesic requirements were less in group B than group A but this was not statistically significant (p>0.05). Conclusion: We believe that 0,125 % bupivacaine can be used in the caudal epidural block of pediatric cases because of its less toxicity and equivalant analgesic properties.