Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.33, sa.3, ss.222-226, 2005 (Scopus)
Aim: The aim of this study was to compare the effects of small-dose dexamethasone-tropisetron combination, tropisetron and saline as placebo on postoperative nausea and vomiting in patients undergoing tympanomastoid surgery under desflurane anaesthesia. Materials and Methods: One hundred five ASA physical status I-II patients aged between 18-65 years scheduled for tympanomastoid surgery were studied. Patients were randomized into three groups in a double-blinded manner. After the induction of anesthesia, Group T(tropisetron group, n=35) received intravenous tropisetron (5 mg), Group TD (tropisetron-dexamethasone group, n=35) received intravenous dexamethasone (5mg) and tropisetron (5 mg) and Group P (placebo group, n=35) received intravenous saline. Anesthesia was maintained with desflurane 5%-7% in O2 33% and N2O 66% mixture. Postoperative nausea and vomiting were evaluated using a 3-point scale: 0=no symptoms, 1=nausea, 2=vomiting. Each episode of postoperative nausea and vomiting was recorded during four periods within the first 24h after the operation: 0-2h, 2-6h, 6-12h and 12-24h. Results: The percentage of postoperative nausea and vomiting among the three groups were 80% in group P, 31.4% in group T and 25.7% in group TD (p<0.05). The percentage of patients who required rescue antiemetics were 11.4% (4 patients) in Group T, 8.6% (3 patients) in Group TD and 40% (14 patients) in Group P. Patients in Group T and Group TD required less rescue antiemetic medications than those in Group P (p<0.05). Also, patients in Group T and Group TD had a less frequent incidence of postoperative nausea and vomiting than those in Group P during the first 12 hours after surgery (p<0.05). VAS scores were lower in Group TD than Group P at 0-2h, and 2-6h periods. Conclusion: Prophylactic administration of either intravenous tropisetron or tropisetron-dexamethasone combination reduces the incidence of postoperative nausea and vomiting in patients undergoing tympanomastoid surgery under desflurane anaesthesia. The addition of dexamethasone was not associated with increased efficacy in preventing nausea or vomiting.