Encapsulation of Flurbiprofen by Chitosan Using a Spray-Drying Method with In Vitro Drug Releasing and Molecular Docking

Akyuz L., Duman F., Kaya M.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.1, pp.34-39, 2017 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.4274/tjps.95867
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.34-39
  • Keywords: Biodegradable, drug delivery, molecular docking, characterization, DELIVERY-SYSTEM, NANOPARTICLES, FORMULATION
  • Erciyes University Affiliated: Yes

Abstract

Objectives: This study aimed to prepare chitosan-flurbiprofen micro-nano spheres as environmentally friendly for drug releasing by spray-drying method without any cross-linking agent. It was also aimed to reveal the favorable binding geometries of chitosan and flurbiprofen using molecular modeling.