Tumour necrosis factor alpha, lipid peroxidation and NO center dot are increased and associated with decreased free-radical scavenging enzymes in patients with Weill-Marchesani syndrome

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Evereklioglu C., Turkoz Y., Calis M., Duygulu F., Karabulut A.

MEDIATORS OF INFLAMMATION, vol.13, no.3, pp.165-170, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1080/09511920410001713547
  • Journal Name: MEDIATORS OF INFLAMMATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.165-170
  • Erciyes University Affiliated: Yes

Abstract

AIM: Weill-Marchesani syndrome (WMS) is a rare systemic disorder with both autosomal recessive and dominant inheritances. Accumulation of reactive oxygen species such as O-2(.-), H2O2 and OH. causes lipid peroxidation (LPO), whereas antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSHPx)) mediate defence against oxidative stress. Excess tumour necrosis factor (TNF)-alpha and NO. react with O-2(.-) and cause further antioxidant depletion with an increase in mutation frequency by H2O2. This study investigated the levels of SOD, GSHPx, catalase (CAT), TNF-alpha, NO. and LPO in patients with WMS.