Tumour necrosis factor alpha, lipid peroxidation and NO center dot are increased and associated with decreased free-radical scavenging enzymes in patients with Weill-Marchesani syndrome


Evereklioglu C. , Turkoz Y., Calis M. , Duygulu F. , Karabulut A.

MEDIATORS OF INFLAMMATION, cilt.13, ss.165-170, 2004 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 13 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/09511920410001713547
  • Dergi Adı: MEDIATORS OF INFLAMMATION
  • Sayfa Sayısı: ss.165-170

Özet

AIM: Weill-Marchesani syndrome (WMS) is a rare systemic disorder with both autosomal recessive and dominant inheritances. Accumulation of reactive oxygen species such as O-2(.-), H2O2 and OH. causes lipid peroxidation (LPO), whereas antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSHPx)) mediate defence against oxidative stress. Excess tumour necrosis factor (TNF)-alpha and NO. react with O-2(.-) and cause further antioxidant depletion with an increase in mutation frequency by H2O2. This study investigated the levels of SOD, GSHPx, catalase (CAT), TNF-alpha, NO. and LPO in patients with WMS.