Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity


Evereklioglu C. , Inaloz H., Kirtak N., Doganay S., Bulbul M., Otlu B., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.147, ss.331-336, 2002 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 147 Konu: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1365-2133.2002.04703.x
  • Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
  • Sayfa Sayıları: ss.331-336

Özet

Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.