A family with two different chromosomal translocations


Ozkul Y., Dundar M.

ANNALES DE GENETIQUE, vol.45, no.4, pp.185-187, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.1016/s0003-3995(02)01145-0
  • Journal Name: ANNALES DE GENETIQUE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.185-187
  • Erciyes University Affiliated: Yes

Abstract

The proband was a 22-year-old woman who had two spontaneous abortions in the first trimester of pregnancy. She had a consanguineous marriage with no history of malformation or developmental disorders in the family. Her gynecological examination was normal. Chromosome analysis of the family showed two different katyotypes 46,XYt(1;16)(p22;p13) and 46,XX,t(1;16)(q24;q24) using high-resolution banding (HRB). Proband's family was also examined for chromosome analysis. A t(1;16)(p22;p13) was found in the husband's father and other relatives, and a t(1;16)(q24;q24) translocation in the proband's family. This second tanslocation is not found in her parents. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.