Akademik Veri Yönetim Sistemi
Microchemical Journal, cilt.224, 2026 (SCI-Expanded, Scopus)
Breast cancer remains a major cause of mortality, with HER2-positive subtypes treated using targeted agents such as neratinib (NER). In this study, a novel electrochemical sensor was developed by modifying a glassy carbon electrode (GCE) with a bimetallic Ag-Cu/SrFe₂O₄ nanocomposite for sensitive detection of NER. The nanocomposite was characterized using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Brunauer–Emmett–Teller (BET), Field Emission Scanning Electron Microscopy (FE-SEM), Energy-Dispersive X-ray Spectroscopy (EDX), and Thermogravimetric Analysis (TGA), confirming its uniform morphology, high surface area, and structural stability. Electrochemical performance was evaluated using differential pulse voltammetry (DPV), revealing a wide linear range of 0.05–3.3 μM, a low detection limit of 0.009 μM, and a limit of quantification of 0.032 μM, with excellent linearity (R2 = 0.998) and stable electron-transfer kinetics. Repeatability (RSD = 2.1%), reproducibility (RSD = 1.1%), and selectivity studies confirmed robust analytical performance even in the presence of common interfering substances. The sensor was effectively employed for the analysis of human blood serum, urine, and pharmaceutical tablet samples, yielding recovery values ranging from 97.07% to 102.68%, with RSDs below 3%. These results establish the Ag–Cu/SrFe₂O₄/GCE sensor as a reliable, precise, and practical platform for trace-level quantification of NER in pharmaceutical and biological matrices.