THE INVESTIGATION of cTNT, cTNI and CK (MB) LEVELS in RATS INDUCED EXPERIMENTALLY ETHYLENE GLYCOL TOXICATION


Güneş V. , Doğan B.

X. INTERNATIONAL MULTIDISCIPLINARY CONGRESS OF EURASIA (IMCOFE), Praha, Çek Cumhuriyeti, 6 - 08 Ağustos 2019, ss.425

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Praha
  • Basıldığı Ülke: Çek Cumhuriyeti
  • Sayfa Sayıları: ss.425

Özet

This project was supported by Erciyes University Scientific Research Council with project number: TYL 2018-8340 The aim of this study was to investigate the possible contributions of cardiac muscle biomarkers (cTnl, cTnT, and CK MB) in pathogenesis of experimentally ethylene glycol (EG) intoxication in rats. The study was conducted on a total of 30 Spraque Dawley rats, 15 females and 15 males with age of 4±1 months, weight of 275±25 gr. The rats were randomly divided into three groups of 10 rats in each group. Group I (High Dose EG): rats given 6 ml / kg EG; Group II (Low Dose EG): rats given 3 ml / kg EG; Group III (Control): rats given the same volume of saline (SF) as the EG. During the study, blood samples were collected from tail and heart in terminal period for biochemical analysis at 0. hour before EG, 72. and at 96th hour after EG. The cTnT and CK (MB) levels obtained after the administration of EG were significantly increased compared to the 0. hour and the control group data, and the cTnI levels were not changed in all groups during study. In group I, the mean cTnT levels before and after EG were 0.013 ± 0.005, 0.041 ± 0.009 and 0.578 ± 0.008 ng / ml respectively; In Group II; 0.043 ± 0.049, 0.177 ± 0.073 and 1.002 ± 0.001 ng / ml respectively. Mean CK (MB) values were found in Group I and II,; 542.67 ± 35.62, 587.67 ± 54.23, 877.50 ± 23.57 and 532.75 ± 110.88, 972.87 ± 781.62, 554.25 ± 10.00 IU / L respectively . In result, it was concluded that cTnT and CK MB levels are useful parameters for monitoring heart muscle damage in EG intoxications in humans or animals. In addition these parameters may use in determination of pathogenesis in EG intoxication.