Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model


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Bahadir A., Ceyhan A., Gergın O. O., Yalçın B., Ülger M., Özyazgan T. M., ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.19, pp.213-221, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2018
  • Doi Number: 10.14744/anatoljcardiol.2018.53059
  • Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.213-221
  • Keywords: cisplatin, cardiotoxicity, curcumin, beta-carotene, rat heart tissue, MOLECULAR-MECHANISMS, LUNG-CANCER, TNF-ALPHA, PREVENTS, DAMAGE, CHEMOTHERAPY, TOXICITY, THERAPY, INJURY
  • Erciyes University Affiliated: Yes

Abstract

Objective: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues.