Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model

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Bahadir A., Ceyhan A., Gergın O. O., Yalçın B., Ülger M., Özyazgan T. M., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.19, ss.213-221, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2018
  • Doi Numarası: 10.14744/anatoljcardiol.2018.53059
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.213-221
  • Anahtar Kelimeler: cisplatin, cardiotoxicity, curcumin, beta-carotene, rat heart tissue, MOLECULAR-MECHANISMS, LUNG-CANCER, TNF-ALPHA, PREVENTS, DAMAGE, CHEMOTHERAPY, TOXICITY, THERAPY, INJURY
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues.