Effect of LED-mediated-photobiomodulation therapy on orthodontic tooth movement and root resorption in rats

Ekizer A., Uysal T., Güray E., AKKUS D.

LASERS IN MEDICAL SCIENCE, cilt.30, sa.2, ss.779-785, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10103-013-1405-3
  • Dergi Adı: LASERS IN MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.779-785
  • Anahtar Kelimeler: Low-level laser therapy, Tooth movement, Orthodontics, Rats, LEVEL LASER THERAPY, LIGHT THERAPY, IRRADIATION, REGENERATION, PHOTOTHERAPY, FIBROBLASTS, RADIATION, COLLAGEN, ENERGY, SKIN
  • Erciyes Üniversitesi Adresli: Evet

Özet

The aim of this experimental study was to evaluate the effects of light-emitting diode-mediated-photobiomodulation therapy (LPT), on the rate of orthodontic tooth movement (TM) and orthodontically induced root resorption, in rats. Twenty male 12-week-old Wistar rats were separated into two groups (control and LPT) and 50 cN of force was applied between maxillary left molar and incisor with a coil spring. In the treatment group, LPT was applied with an energy density of 20 mW/cm(2) over a period of 10 consecutive days directly over the movement of the first molar teeth area. The distance between the teeth was measured with a digital caliper on days 0 (T0), 10 (T1), and 21 (T2) on dental cast models. The surface area of root resorption lacunae was measured histomorphometrically using digital photomicrographs. Mann-Whitney U and Wilcoxon tests were used for statistical evaluation at p < 0.05 level. TM during two different time intervals (T1-T0 and T2-T1) were compared for both groups and a statistically significant difference was found in the LPT group (p = 0.016). The TM amount at the first time period (1.31 +/- 0.36 mm) was significantly higher than the second time period (0.24 +/- 0.23 mm) in the LPT group. Statistical analysis showed significant differences between two groups after treatment/observation period (p = 0.017). The magnitude of movement in the treatment group was higher (1.55 +/- 0.33 mm) compared to the control group (1.06 +/- 0.35 mm). Histomorphometric analysis of root resorption, expressed as a percentage, showed that the average relative root resorption affecting the maxillary molars on the TM side was 0.098 +/- 0.066 in the LPT group and 0.494 +/- 0.224 in the control group. Statistically significant inhibition of root resorption with LPT was determined (p < 0.001) on the TM side. The LPT method has the potential of accelerating orthodontic tooth movement and inhibitory effects on orthodontically induced resorptive activity.