Diagnostic Modalities Based on Flow Cytometry for Chronic Granulomatous Disease: A Multicenter Study in a Well-Defined Cohort

Baris, Hatice; ÖĞÜLÜR, İSMAİL; Akcam, Bengu; KIYKIM, Ayça; Karagoz, Dilek; SARAYMEN, BERKAY; Akgun, Gamze; Eltan, Sevgi; Aydemir, Sezin; Akidagi, Zeynep; Bentli, Esma; Nain, Ercan; Kasap, Nurhan; Baser, Dilek; Altintas, Derya; Camcioglu, Yildiz; Yesil, Gozde; Ozen, Ahmet; KÖKER, MUSTAFA; Karakoc-Aydiner, Elif; Baris, Safa

doi:10.1016/j.jaip.2020.07.030

Diagnostic Modalities Based on Flow Cytometry for Chronic Granulomatous Disease: A Multicenter Study in a Well-Defined Cohort

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Baris H. E., ÖĞÜLÜR İ., Akcam B., KIYKIM A., Karagoz D., SARAYMEN B., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, vol.8, no.10, pp.3525-3535, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 8 Issue: 10
Publication Date: 2020
Doi Number: 10.1016/j.jaip.2020.07.030
Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Page Numbers: pp.3525-3535
Keywords: Chronic granulomatous disease, NADPH oxidase, flow cytometry, Dihydrorhodamine, gp91, p22, p47, p67, MUTATIONS, DIHYDRORHODAMINE, OXIDASE, ASSAY, FAMILIES, CARRIERS, TURKEY, BURST
Erciyes University Affiliated: Yes

Abstract

BACKGROUND: Chronic granulomatous disease (CGD) is characterized by defective microbial killing due to mutations affecting subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Definitive genetic identification of disease subtypes may be delayed or not readily available.