The aim of this study is to examine and compare the effects of topical prostacyclin and prostaglandin E, on flap survival after nicotine application in rats. In the designed experiment, group I was treated with I mL saline, and groups 2, 3, and 4 were treated with 2 mg/kg of nicotine subcutaneously for 4 weeks. At the end of 4 weeks, surgery was done, and topical applications of vaseline base on groups I and 2, prostacyclin (PgI(2)-iloprost) on group 3, and prostaglandin E-1 (PgE(1)-misoprostol) on group 4 were performed. At the end of the seventh day following the operation, all survival areas in all groups were identified. For groups 1, 2, 3, and 4, survival areas were measured as 59.05% +/- 5.13%, 50.40% +/- 4.74%, 67.89% +/- 4.69%, and 62.45% +/- 7.80%, respectively. As a result, the authors concluded that survival areas can be increased with topical applications of these prostaglandins on the flaps (that are under nicotine effect), and there were no differences between these 2 medications in terms of flap survival.