Thymoquinone Inhibits Proliferation and Migration of MDA-MB-231 Triple Negative Breast Cancer Cells by Suppressing Autophagy and Beclin-1 and LC3.


Ünal T., Hamurcu Z. , Delibaşı N., Çınar V., Güler A., Gökçe S., ...More

Anti-cancer agents in medicinal chemistry, vol.21, pp.355-364, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520620666200807221047
  • Title of Journal : Anti-cancer agents in medicinal chemistry
  • Page Numbers: pp.355-364
  • Keywords: Thymoquinone, autophagy, Nigella sativa, LC3, Beclin-1, Integrin-01, VEGF, MMP-2, MMP-9, breast cancer, treatment, invasion, angiogenesis, EPITHELIAL-MESENCHYMAL TRANSITION, TARGETING AUTOPHAGY, ANTITUMOR-ACTIVITY, LUNG-CANCER, EXPRESSION, ANGIOGENESIS, ACTIVATION, APOPTOSIS, OSTEOSARCOMA, STRATEGIES

Abstract

Background: Triple Negative Breast Cancer (TNBC) is an aggressive and highly heterogeneous subtype of breast cancer associated with poor prognosis. A better understanding of the biology of this complex cancer is needed to develop novel therapeutic strategies for the improvement of patient survival. We have previously demonstrated that Thymoquinone (TQ), the major phenolic compound found in Nigella sativa, induces anti-proliferative and anti-metastatic effects and inhibits in vivo tumor growth in orthotopic TNBC models in mice. Also, we have previously shown that Beclin-1 and LC3 autophagy genes contributes to TNBC cell proliferation, migration and invasion, suggesting that Beclin-1 and LC3 genes provide proto-oncogenic effects in TNBC. However, the role of Beclin-1 and LC3 in mediating TQ-induced anti-tumor effects in TNBC is not known.