Predictors of poor kidney outcome in children with C3 glomerulopathy

Pınarbaşı, AYŞE; Dursun, İSMAİL; Gökce, İbrahim; Çomak, Elif; Saygili, Seha; Bayram, Meral; Dönmez, Osman; Melek, Engin; Tekcan, Demet; Cicek, Neslihan; Yılmaz, Dilek; Tabel, Yılmaz; Yildirim, Zeynep; Bahat Özdoğan, Elif; Koyun, Mustafa; Soylu, Alper; Canpolat, Nur; Aksu, Bagdagul; Celakil, Mehtap; Tasdemir, Mehmet; Benzer, Meryem; Ozcelik, Gul; Bakkaloğlu Ezgü, Sevcan; Düşünsel, Ruhan

doi:10.1007/s00467-020-04799-7

Predictors of poor kidney outcome in children with C3 glomerulopathy

Atıf İçin Kopyala

Pınarbaşı A. S., Dursun İ., Gökce İ., Çomak E., Saygili S., Bayram M. T., ...Daha Fazla

PEDIATRIC NEPHROLOGY, cilt.36, sa.5, ss.1195-1205, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 36 Sayı: 5
Basım Tarihi: 2021
Doi Numarası: 10.1007/s00467-020-04799-7
Dergi Adı: PEDIATRIC NEPHROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.1195-1205
Anahtar Kelimeler: Complement, CKD stage 5, Children, C3 glomerulopathy, Predictors, DENSE DEPOSIT DISEASE, MYCOPHENOLATE-MOFETIL, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, POSTINFECTIOUS GLOMERULONEPHRITIS, ECULIZUMAB, EXPERIENCE
Erciyes Üniversitesi Adresli: Evet

Özet

Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G.