Preclinical evaluation of a new left atrial appendage occluder (Lifetech LAmbre (TM) Device) in a canine model

Lam Y., Yan B. P. , Doshi S. K. , Lİ A., Zhang D., KAYA M., ...Daha Fazla

INTERNATIONAL JOURNAL OF CARDIOLOGY, cilt.168, sa.4, ss.3996-4001, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 168 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.ijcard.2013.06.083
  • Sayfa Sayıları: ss.3996-4001


Objectives: The study evaluated the feasibility and safety of a novel left atrial appendage (LAA) occluder (LAmbre (TM), Lifetech Scientific Corp., China) in canines.



The study evaluated the feasibility and safety of a novel left atrial appendage (LAA) occluder (LAmbre,

Lifetech Scienti


fic Corp., China) in canines.



Transcatheter LAA occlusion is comparable towarfarin in preventing atrial fibrillation-related strokes.



Twenty-two healthy dogs (28 ± 3 kg) received LAmbre implants. The device is delivered by an



10 French sheath and has full recapture and repositioning capabilities. All dogs received 1-week antibiotics

and 4-week aspirin (80 mg daily) after implants and they were sacri


ficed in groups at Days 13

(n = 5), 1- (n = 7), 3- (n = 4) and 6-months (n = 6) for pathological examinations. Transthoracic

echocardiography (TTE) was performed immediately after implant, at Day 3 and before sacri





The LAmbre was successfully implanted, retrieved, repositioned and re-implanted in all dogs. The

mean implant size was 24 ± 3 mm and the device chosen was 36 ± 7% larger than the measured landing

zone diameter. Improper device selection (only 21% oversizing) resulted in dislodgement and death of 1

dog on Day 3. Post-implant angiography and TTE showed well-positioned device without pericardial

effusion or impingement on surrounding structures. Late complications included device-related thrombus at

1 month (n = 1) and clinically insigni


ficant pericardial effusion at Day 3 (n = 1). Complete healing on the atrial

facing surface with optimal LAA obliteration was con


firmed by gross andmicroscopic examinations in dogs that

have been followed up


3 months (n=10). No infarctwas detected inmajor organs.



Our preliminary data suggested the LAmbredevice is feasible with high success rate in canines.

Further studies are needed to evaluate its safety and ef