Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: A controlled study

DENİZ K., YÜCE I., ÇAĞLI S., Okten T., Guney E.

ENT-EAR NOSE & THROAT JOURNAL, cilt.87, sa.8, ss.469-473, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 8
  • Basım Tarihi: 2008
  • Dergi Adı: ENT-EAR NOSE & THROAT JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.469-473
  • Erciyes Üniversitesi Adresli: Evet

Özet

We investigated the difference In the biologic nature of typical squamous cell Carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers. We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC. We found no significant difference between the two groups in the PCNA index or the frequency of bcl-2 overexpression, nor did we find and significant difference in survival. Our findings Indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar. In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.