A rare complication of brucellosis is presented. A 23-year old man was admitted to the hospital with fever, chills, fatigue, dyspnea, and rash. The patient was diagnosed as brucellosis by the isolation Brucelia melitensis (B. melitensis) from blood and cerebrospinal fluid cultures. Multisystemic involvement; pneumonia, meningitis, hepatitis, endocarditis, cutaneous lesions and hematological abnormalities were observed. Adult respiratory distress syndrome (ARDS) developed. The patient treated with a combination of ceftriaxone, doxycycline and rifampicin, was operated for mitral valve replacement. Relapse has not been observed.