A total of 17 patients who diagnosed as genitourinary tuberculosis between the period of 1990 and 1995, in the Urology Department of Erciyes University Medical Faculty, were included in this study in order to evaluate the effectiveness of 6 months-antituberculosis treatment on genitourinary tuberculosis. Diagnosis was established with the help of urinary tuberculosis culture and intravenous urography in most of the patients, with histopathological examination in two renal and two other epididimal tuberculosis cases. One patient was diagnosed with the positive response to the treatment. All of the patients were treated with antituberculosis drugs during 6 months. After the treatment on 3rd, 6th, 12th, 18th and 24th months, all of the patients were followed by the presence of urinary acid-fast bacteria, tuberculosis culture and antibiograms and, when necessary, with intravenous urography. Ten of the patients were male and seven were female. None of the patients had previous diagnosis or family history of tuberculosis, and except for five patients, all had normal lung X-rays at the time of diagnosis. Two of the patients have not been recovered because of the resistance to antimicrobials; therefore, 18-monthly another protocol of antituberculotics had to be used for the complete microbiological recovery. The remaining fifteen patients had no recurrence during the follow-up of at least 18 months. Although it has been reported that the resistance to antituberculosis drugs has increased progressively recently, 6-months-antituberculosis therapy seems to have satisfactory results for the treatment of genitourinary tuberculosis. Extensive studies of large numbers of patients with regular follow-up are necessary to have objective conclusions.