Intravenous N-acetylcysteine plus high-dose hydration versus high-dose hydration and standard hydration for the prevention of contrast-induced nephropathy: CASIS-A multicenter prospective controlled trial


Koc F., Ozdemir K., Kaya M. G. , Dogdu O. , Vatankulu M. A. , Ayhan S., ...More

INTERNATIONAL JOURNAL OF CARDIOLOGY, vol.155, no.3, pp.418-423, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 155 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ijcard.2010.10.041
  • Title of Journal : INTERNATIONAL JOURNAL OF CARDIOLOGY
  • Page Numbers: pp.418-423

Abstract

Background: Contrast-induced nephropathy (CIN) is a leading cause of acute renal failure and affects mortality and morbidity. We investigated the efficacy of prophylactic intravenous (IV) N-acetylcysteine (NAC) and hydration for the prevention of CIN in patients with mild to moderate renal dysfunction who are undergoing coronary angiography and/or percutaneous coronary intervention (PCI).