Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3 beta, beta-secretase, and casein kinase 1 delta


Gürbüz P. , Martinez A., Perez C., Martinez-Gonzalez L., Goger F., Ayran I.

INDUSTRIAL CROPS AND PRODUCTS, vol.138, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 138
  • Publication Date: 2019
  • Doi Number: 10.1016/j.indcrop.2019.05.080
  • Title of Journal : INDUSTRIAL CROPS AND PRODUCTS
  • Keywords: Amyloid beta, Lamiaceae, GSK-3 beta, Alzheimer's disease, Origanum onites, LC-DAD-ESI-MS/MS, ROSMARINUS-OFFICINALIS L., INDUCED NEUROTOXICITY, SALVIA-MILTIORRHIZA, PHENOLIC-COMPOUNDS, FIBRIL FORMATION, ESSENTIAL OILS, 1 DELTA, ACETYLCHOLINESTERASE, INHIBITION, EXTRACT

Abstract

The aerial parts of Lamiaceae plants have been used since ancient times all over the world, especially in Mediterranean cultures, for their medicinal and culinary properties. Although some of them have a historical role in the improvement of cognition and memory, the precise mechanism of these plants remains unclear.