Changes in MAP-2 and GFAP immunoreactivity in pup hippocampus during prepubertal and pubertal periods caused by maternal subclinical hypothyroidism

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Yildirim A. B., Ozdamar S., Yalçın B., Karabulut D.

EUROPEAN JOURNAL OF ANATOMY, vol.23, pp.27-40, 2019 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2019
  • Journal Name: EUROPEAN JOURNAL OF ANATOMY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.27-40
  • Erciyes University Affiliated: Yes

Abstract

An absence of the thyroid hormone during the critical period of brain development causes delayed maturation of glial cells and neurons and decreases the number of hippocampal cells. This study aims to examine the impact of maternal subclinical hypothyroidism (SCH) on pup hippocampus during the prepubertal and pubertal periods by means of assessing the histopathological changes in astrocytes and neurons.